Simultaneous Determination of the Conformation and Relative Configuration of 
Archazolide A by Using Nuclear Overhauser Effects, J Couplings, and Residual 
Dipolar Couplings

Farès, Christophe; Hassfeld, Jorma; Menche, Dirk; Carlomagno, Teresa

doi:10.1002/anie.200800225

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Simultaneous Determination of the Conformation and Relative Configuration of Archazolide A by Using Nuclear Overhauser Effects, J Couplings, and Residual Dipolar Couplings

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Farès, Christophe
Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society;

Carlomagno, Teresa
Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Farès, C., Hassfeld, J., Menche, D., & Carlomagno, T. (2008). Simultaneous Determination of the Conformation and Relative Configuration of Archazolide A by Using Nuclear Overhauser Effects, J Couplings, and Residual Dipolar Couplings. Angewandte Chemie International Edition, 47(20), 3722-3726. doi:10.1002/anie.200800225.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-4A10-4

Abstract

Combine and conquer: Configurational assignment of remote stereogenic centers in the complex polyketide macrolide archazolide A (see structure; red O, blue N, yellow S) was accomplished by a purely NMR-based approach relying on a combination of nuclear Overhauser effects, J couplings, and residual dipolar couplings (RDCs).