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Stereochemical Determination of Archazolid A and B, Highly Potent Vacuolar-Type ATPase Inhibitors from the Myxobacterium Archangium gephyra

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Farès,  C.
Service Department Farès (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Max Planck Institute for Biophysical Chemistry, Department of NMR based Structural Biology, Am Fassberg, 11, D-37077 Göttingen, Germany ;

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Citation

Hassfeld, J., Farès, C., Steinmetz, H., Carlomagno, T., & Menche, D. (2006). Stereochemical Determination of Archazolid A and B, Highly Potent Vacuolar-Type ATPase Inhibitors from the Myxobacterium Archangium gephyra. Organic Letters, 8(21), 4751-4751. doi:10.1021/ol061831y.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-4B39-B
Abstract
The relative and absolute stereochemistry of the structurally unique 24-membered myxobacterial macrolides archazolid A and B, highly potent vacuolar-type ATPase (V-ATPase) inhibitors in vitro and in vivo, was determined on the basis of a combination of extensive high-field NMR studies, including J-based configuration analysis, molecular modeling, and chemical methods.