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Journal Article

Stereochemical Determination of Archazolid A and B, Highly Potent Vacuolar-Type ATPase Inhibitors from the Myxobacterium Archangium gephyra

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Farès,  Christophe
Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society;

Carlomagno,  Teresa
Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Hassfeld, J., Farès, C., Steinmetz, H., Carlomagno, T., & Menche, D. (2006). Stereochemical Determination of Archazolid A and B, Highly Potent Vacuolar-Type ATPase Inhibitors from the Myxobacterium Archangium gephyra. Organic Letters, 8(21), 4751-4751. doi:10.1021/ol061831y.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-4B39-B
Abstract
The relative and absolute stereochemistry of the structurally unique 24-membered myxobacterial macrolides archazolid A and B, highly potent vacuolar-type ATPase (V-ATPase) inhibitors in vitro and in vivo, was determined on the basis of a combination of extensive high-field NMR studies, including J-based configuration analysis, molecular modeling, and chemical methods.