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Membrane tension drives ligand-independent integrin signaling

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Böttcher,  Ralph Thomas
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Fässler,  Reinhard
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Böttcher, R. T., & Fässler, R. (2014). Membrane tension drives ligand-independent integrin signaling. EMBO JOURNAL, 33(21), 2439-2441. doi:10.15252/embj.201489886.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-59D8-7
Abstract
Integrins anchor cells to the extracellular matrix (ECM) and control a multitude of essential cellular functions by activating a variety of signaling pathways. In this issue of The EMBO Journal, a study conducted by Ferraris and colleagues report that binding of urokinase-type plasminogen activator receptor (uPAR) to vitronectin is sufficient to trigger ligand-independent 1 and 3 integrin signaling. The coupling of uPAR and integrins occurs independent of lateral interaction between the two receptors, but relies on membrane tension (Ferraris etal, ).