English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Microbial view of central nervous system autoimmunity

MPS-Authors
/persons/resource/persons38762

Berer,  Kerstin
Emeritus Group: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38946

Krishnamoorthy,  Gurumoorthy
Emeritus Group: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Berer, K., & Krishnamoorthy, G. (2014). Microbial view of central nervous system autoimmunity. FEBS LETTERS, 588(22), 4207-4213. doi:10.1016/j.febslet.2014.04.007.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-59A8-4
Abstract
Not much is known about the initial events leading to the development of the central nervous system (CNS)-specific autoimmune disorder Multiple Sclerosis (MS). Environmental factors are suspected to trigger the pathogenic events in people with genetic disease susceptibility. Historically, many infectious microbes were linked to MS, but no infection has ever been demonstrated to be the cause of the disease. Recent emerging evidence from animal models of MS suggests a causal link with resident commensal bacteria. Microbial organisms may trigger the activation of CNS-specific, auto-aggressive lymphocytes either through molecular mimicry or via bystander activation. In addition, several gut microbial metabolites and bacterial products may interact with the immune system to modulate CNS autoimmunity. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.