English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

SR1, a Mouse Odorant Receptor with an Unusually Broad Response Profile

MPS-Authors
/persons/resource/persons137810

Mombaerts,  Peter
Department of Molecular Neurogenetics, Max Planck Institute of Biophysics, Max Planck Society;
The Rockefeller University, New York, New York 10065, USA;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Grosmaitre, X., Fuss, S. H., Lee, A. C., Adipietro, K. A., Matsunami, H., Mombaerts, P., et al. (2009). SR1, a Mouse Odorant Receptor with an Unusually Broad Response Profile. The Journal of Neuroscience, 29(46), 14545-14552. doi:10.1523/JNEUROSCI.2752-09.2009.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-D739-9
Abstract
The current consensus model in mammalian olfaction is that the detection of millions of odorants requires a large number of odorant receptors (ORs) and that each OR interacts selectively with a small subset of odorants, which are typically related in structure. Here, we report the odorant response properties of an OR that deviates from this model: SR1, a mouse OR that is abundantly expressed in sensory neurons of the septal organ and also of the main olfactory epithelium. Patch-clamp recordings reveal that olfactory sensory neurons (OSNs) that express SR1 respond to many, structurally unrelated odorants, and over a wide concentration range. Most OSNs expressing a gene-targeted SR1 locus that lacks the SR1 coding sequence do not show this broad responsiveness. Gene transfer in the heterologous expression system Hana3A confirms the broad response profile of SR1. There may be other mouse ORs with such broad response profiles.