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Journal Article

Transporter Assays Using Solid Supported Membranes: A Novel Screening Platform for Drug Discovery

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Watzke,  Natalie
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Fendler,  Klaus
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Kelety, B., Diekert, K., Tobien, J., Watzke, N., Dörner, W., Obrdlik, P., et al. (2006). Transporter Assays Using Solid Supported Membranes: A Novel Screening Platform for Drug Discovery. Assay and Drug Development Technologies, 4(5), 575-582. doi:10.1089/adt.2006.4.575.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-D945-C
Abstract
Transporters are important targets in drug discovery. However, high throughput-capable assays for this class of membrane proteins are still missing. Here we present a novel drug discovery platform technology based on solid supported membranes. The functional principles of the technology are described, and a sample selection of transporter assays is discussed: the H(+)-dependent peptide transporter PepT1, the gastric proton pump, and the Na(+)/Ca(2+) exchanger. This technology promises to have an important impact on the drug discovery process.