Electrophysiology in carrier research

Schwarz, W.

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Electrophysiology in carrier research

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Schwarz, W.
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Schwarz, W. (2002). Electrophysiology in carrier research. Biologicheskie Membrany, 19(1), 66-76.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-DC45-1

Abstract

Carrier-mediated transport can be investigated by means of electrophysiological techniques only in large surface areas with a high density of transporters. The Xenopus oocytes have turned out to be an ideal system for functional characterisation of carrier transport, to elucidate structure-function relationships, mechanisms of drug action and the background of phathophysiology conditions. This will be illustrated with three examples of carriers expressed in the oocytes: the Na⁺, K⁺-ATPase, the Na⁺-driven transporter for GABA GAT1, and the anion exchanger of red blood cells AE1.