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Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

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Benjdia,  Alhosna
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Winkler,  Andreas
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Schlichting,  Ilme
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Benjdia, A., Heil, K., Winkler, A., Carell, T., & Schlichting, I. (2014). Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase. Chemical Communications, 50(91), 14201-14204. doi:10.1039/C4CC05158K.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-947D-E
Abstract
The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.