English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin

MPS-Authors
/persons/resource/persons93388

Herb,  Anne
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons95292

Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://www.sciencedirect.com/science/article/pii/S1044743196905941/pdf?md5=0cb6f4e0610d4ea1e6ebd79485484872&pid=1-s2.0-S1044743196905941-main.pdf
(Any fulltext)

http://dx.doi.org/10.1006/mcne.1996.0594
(Any fulltext)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Herb, A., Wisden, W., Catania, M. V., Marechal, D., Dresse, A., & Seeburg, P. H. (1997). Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin. Molecular and Cellular Neuroscience, 8(5), 367-374. doi:10.1006/mcne.1996.0594.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-B4C7-E
Abstract
A recently cloned rat brain cDNA derives from a novel gene, termed dendrin (DEN), expressed exclusively in forebrain structures, particularly in neocortex, olfactory bulb, hippocampus, caudate-putamen, and limbic system. In these structures, the cognate mRNA is present in neuronal cell bodies and their dendrites, whereas near exclusive dendritic localization is observed for the polypeptide product. In the hippocamus, DEN mRNA is highly expressed in the cell laminae and dendritic layers of the dentate gyrus and CA1 field, but expression is markedly reduced in the CA3 and CA4 areas. The predicted primary structure of the hydrophilic, highly basic 653-amino-acid polypeptide does not suggest a function. The restricted expression and dendritic location are compatible with a role for DEN in synaptic plasticity of central neocortical forebrain neurons