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Journal Article

Mammalian RNA dependent deaminases and edited mRNAs

MPS-Authors
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Maas,  Stefan
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Melcher,  Thorsten
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://www.sciencedirect.com/science/article/pii/S0955067497800063/pdf?md5=70387d0c3eb3ffb2da8001ce07bbed19&pid=1-s2.0-S0955067497800063-main.pdf
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http://dx.doi.org/10.1016/S0955-0674(97)80006-3
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Citation

Maas, S., Melcher, T., & Seeburg, P. H. (1997). Mammalian RNA dependent deaminases and edited mRNAs. Current Opinion in Cell Biology, 9(3), 343-349. doi:10.1016/S0955-0674(97)80006-3.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-B4FA-B
Abstract
The past year has witnessed major progress in the field of mammalian nuclear RNA editing. Two new sequence-related RNA-dependent adenosine deaminases, distantly related to the previously characterized double-stranded RNA adenosine deaminase DRADA/dsRAD, have been molecularly characterized. One of these deaminases edits in vitro with precision for the molecular determinant that controls the Ca2+ permeability of fast synaptic glutamate-gated cation channels. This deaminase, like DRADA, is expressed in many tissues and the search is now on for more substrates of these RNA-editing enzymes. Moreover, the physiological role of the apolipoprotein B RNA editing enzyme APOBEC-1 has been investigated in genetically manipulated mice