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Journal Article

Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promotorsubunit NR2C promotor

MPS-Authors
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Suchanek,  Bettina
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfeventlink/$002fj$002fbchm.1997.378.issue-8$002fbchm.1997.378.8.923$002fbchm.1997.378.8.923.xml?format=INT&t:ac=j$002fbchm.1997.378.issue-8$002fbchm.1997.378.8.923$002fbchm.1997.378.8.923.xml
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http://dx.doi.org/10.1515/bchm.1997.378.8.923
(Any fulltext)

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Citation

Suchanek, B., Seeburg, P. H., & Sprengel, R. (1997). Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promotorsubunit NR2C promotor. Biological Chemistry, 378, 929-934. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9377491.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-B746-9
Abstract
In the mouse brain, the N-methyl-D-aspartate receptor subunit NR2C (e-3) is mainly detected in the cerebellar granule cells starting from the second week of postnatal life. In order to improve our understanding of molecular mechanisms of this neuron-specific, spatial and temporal gene expression, different promoter fragments were used to control indicator genes in nondifferentiated rat pheochromocytoma (PC12) cells, in human embryonal kidney (HEK293) cells and in transgenic mice. A 400 bp NR2C promoter region upstream of the transcriptional start site was identified as a basal promoter that was negatively regulated possibly by a neuron restrictive silencer element (NRSE) that is localized 664 base pairs downstream from the tanscriptional start sites