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Journal Article

Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments

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Acevedo-Rocha,  Carlos G.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität Marburg;

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Wiltschi,  Birgit
MPI for Polymer Research, Max Planck Society;

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Citation

Acevedo-Rocha, C. G., Hoesl, M., Nehring, S., Royter, M., Wolschner, C., Wiltschi, B., et al. (2013). Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments. Catalysis Science & Technology, (5). doi:10.1039/C3CY20712A.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-BBC5-B
Abstract
The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to 450%) and surfactants (resp. 1630%), but also protective effects against protein reducing (resp. 140%), alkylating (resp. 160%), and denaturing (resp.190%) agents as well as inhibitors (resp. 40%). This approach offers novel chemically diversified biocatalysts for hostile environments.