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Journal Article

Multi layer chromosome organization through DNA bending, bridging and extrusion


Gruber,  Stephan
Gruber, Stephan / Chromosome Organization and Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Gruber, S. (2014). Multi layer chromosome organization through DNA bending, bridging and extrusion. CURRENT OPINION IN MICROBIOLOGY, 22, 102-110. doi:10.1016/j.mib.2014.09.018.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-C4AB-2
All living cells have to master the extraordinarily extended and tangly nature of genomic DNA molecules in particular during cell division when sister chromosomes are resolved from one another and confined to opposite halves of a cell. Bacteria have evolved diverse sets of proteins, which collectively ensure the formation of compact and yet highly dynamic nucleoids. Some of these players act locally by changing the path of DNA through the bending of its double helical backbone. Other proteins have wider or even global impact on chromosome organization, for example by interconnecting two distant segments of chromosomal DNA or by actively relocating DNA within a cell. Here, I highlight different modes of chromosome organization in bacteria and on this basis consider models for the function of SMC protein complexes, whose mechanism of action is only poorly understood so far.