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Journal Article

Molecular mechanisms of long ncRNAs in neurological disorders

MPS-Authors
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Vucicevic,  Dubravka
Long non-coding RNA (Ulf Andersson Ørom), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Schrewe,  Heinrich
Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Ørom,  Ulf Andersson
Long non-coding RNA (Ulf Andersson Ørom), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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http://www.ncbi.nlm.nih.gov/pubmed/24624135
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Fulltext (public)

Vučićević.pdf
(Publisher version), 851KB

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Citation

Vucicevic, D., Schrewe, H., & Ørom, U. A. (2014). Molecular mechanisms of long ncRNAs in neurological disorders. Frontiers in Genetics, 5: 5:48. doi:10.3389/fgene.2014.00048.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0025-781E-D
Abstract
Long non-coding RNAs (ncRNAs) have added an unexpected layer of complexity in the regulation of gene expression. Mounting evidence now links long ncRNAs to fundamental biological processes such as development and differentiation, and recent research shows important involvement of long ncRNAs in a variety of diseases including neurodegenerative disorders, such as Parkinson's, Alzheimer's, spinocerebellar ataxia, and Huntington's diseases. Furthermore, long ncRNAs are speculated to be implicated in development of psychiatric disorders such as schizophrenia and bipolar disorders. Long ncRNAs contribute to these disorders in diverse ways, from regulation of transcription to modulation of RNA processing and translation. In this review, we describe the diverse mechanisms reported for long ncRNAs, and discuss how they could mechanistically be involved in the development of neurological disorders.