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How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors

MPG-Autoren
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Cost,  Anna-Lena
Grashoff, Carsten / Molecular Mechanotransduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Ringer,  Pia
Grashoff, Carsten / Molecular Mechanotransduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Chrostek-Grashoff,  Anna
Grashoff, Carsten / Molecular Mechanotransduction, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons78025

Grashoff,  Carsten
Grashoff, Carsten / Molecular Mechanotransduction, Max Planck Institute of Biochemistry, Max Planck Society;

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art%3A10.1007%2Fs12195-014-0368-1.pdf
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Zitation

Cost, A.-L., Ringer, P., Chrostek-Grashoff, A., & Grashoff, C. (2015). How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors. Cellular and Molecular Bioengineering, 8(1), 96-105. doi:10.1007/s12195-014-0368-1.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0025-A9A5-5
Zusammenfassung
The ability of cells to sense and respond to mechanical forces is central to a wide range of biological processes and plays an important role in numerous pathol- ogies. The molecular mechanisms underlying cellular mech- anotransduction, however, have remained largely elusive because suitable methods to investigate subcellular force propagation were missing. Here, we review recent advances in the development of biosensors that allow molecular force measurements. We describe the underlying principle of currently available techniques and propose a strategy to systematically evaluate new Fo ̈ rster resonance energy trans- fer (FRET)-based biosensors