Threshold limits for biological indication of prolonged radiation exposure 
using mFISH

Osovets, S. V.; Sotnik, N. V.; Meineke, V.; Scherthan, H.; Dorr, H.; Azizova, T. V.

doi:10.1097/HP.0000000000000057

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Threshold limits for biological indication of prolonged radiation exposure using mFISH

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Scherthan, H.
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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http://www.ncbi.nlm.nih.gov/pubmed/24776899
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Citation

Osovets, S. V., Sotnik, N. V., Meineke, V., Scherthan, H., Dorr, H., & Azizova, T. V. (2014). Threshold limits for biological indication of prolonged radiation exposure using mFISH. Health Physics, 106(6), 677-681. doi:10.1097/HP.0000000000000057.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0025-C1AA-A

Abstract

Chromosome aberration (translocation) yield was investigated by mFISH in peripheral blood lymphocytes of Mayak Production Association (PA) workers with prolonged occupational exposure to ionizing radiation (IR). A dose threshold for cytogenetic indication of a prolonged occupational radiation exposure was estimated for Mayak PA workers using functions of dose distributions. Two limits were estimated for the indication of IR exposure to workers with a prolonged external gamma-ray exposure: These are a background translocation yield of N(0) = 0.812 +/- 0.149% and a dose threshold of indication D(0) estimated to be approximately 1 Gy.