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Journal Article

Species differences in bacterial NhaA Na+/H+ exchangers

MPS-Authors
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Calinescu,  Octavian
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Danner,  Eva
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Böhm,  Marc
Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max Planck Society;

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Fendler,  Klaus
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Calinescu, O., Danner, E., Böhm, M., Hunte, C., & Fendler, K. (2014). Species differences in bacterial NhaA Na+/H+ exchangers. FEBS Letters, 588(17), 3111-3116. doi:10.1016/j.febslet.2014.05.066.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-B0BD-7
Abstract
Bacteria have adapted their NhaA Na+/H+ exchangers responsible for salt homeostasis to their different habitats. We present an electrophysiological and kinetic analysis of NhaA from Helicobacter pylori and compare it to the previously investigated exchangers from Escherichia coli and Salmonella typhimurium. Properties of all three transporters are described by a simple model using a single binding site for H+ and Na+. We show that H. pylori NhaA only has a small acidic shift of its pH-dependent activity profile compared to the other transporters and discuss why a more drastic change in its pH activity profile is not physiologically required.