Expedient Preparation of Trifluoromethyl-Substituted Benzofuranols

Morandi, Bill; Carreira, Erick M.

doi:10.1021/ol202423s

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Expedient Preparation of Trifluoromethyl-Substituted Benzofuranols

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Morandi, Bill
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland;

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Citation

Morandi, B., & Carreira, E. M. (2011). Expedient Preparation of Trifluoromethyl-Substituted Benzofuranols. Organic Letters, 13(22), 5984-5985. doi:10.1021/ol202423s.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-A20E-4

Abstract

Direct access to 3-trifluoromethyl-substituted benzofuranols is presented. The products are obtained in good yields from commercially available salicylaldehydes by using in situ generated trifluoromethyl diazomethane and boron trifluoride as an activator. As shown in a representative example, the products can be transformed into the corresponding trifluoromethyl-substituted benzofurans.