English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Rhodium-Catalyzed Cyclopropenation of Alkynes: Synthesis of Trifluoromethyl-Substituted Cyclopropenes

MPS-Authors
/persons/resource/persons145542

Morandi,  Bill
Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland) ;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Morandi, B., & Carreira, E. M. (2010). Rhodium-Catalyzed Cyclopropenation of Alkynes: Synthesis of Trifluoromethyl-Substituted Cyclopropenes. Angewandte Chemie International Edition, 49(25), 4294-4296. doi:1002/anie.201000787.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-A1C0-5
Abstract
Make it strained and fluorinated! A rhodium-catalyzed domino diazotization/cyclopropenation reaction involving trifluoroethylamine hydrochloride and alkynes has been developed for the synthesis of trifluoromethyl cyclopropenes that can be easily functionalized to afford useful CF3-containing building blocks for drug discovery.