Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting.

Caliskan, N.; Peske, F.; Rodnina, M. V.

doi:10.1016/j.tibs.2015.03.006

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Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting.

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Caliskan, N.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

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Peske, F.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

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Rodnina, M. V.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/S0968000415000444/pdfft?md5=26bb65c7bb43fd3c9796b8db03fb5a50&pid=1-s2.0-S0968000415000444-main.pdf
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Citation

Caliskan, N., Peske, F., & Rodnina, M. V. (2015). Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting. Trends in Biochemical Sciences, 40(5), 265-274. doi:10.1016/j.tibs.2015.03.006.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-B76A-7

Abstract

Programmed −1 ribosomal frameshifting (−1PRF) is an mRNA recoding event commonly utilized by viruses and bacteria to increase the information content of their genomes. Recent results have implicated −1PRF in quality control of mRNA and DNA stability in eukaryotes. Biophysical experiments demonstrated that the ribosome changes the reading frame while attempting to move over a slippery sequence of the mRNA – when a roadblock formed by a folded downstream segment in the mRNA stalls the ribosome in a metastable conformational state. The efficiency of −1PRF is modulated not only by cis-regulatory elements in the mRNA but also by trans-acting factors such as proteins, miRNAs, and antibiotics. These recent results suggest a molecular mechanism and new important cellular roles for −1PRF.