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Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting.

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Caliskan,  N.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

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Peske,  F.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

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Rodnina,  M. V.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Caliskan, N., Peske, F., & Rodnina, M. V. (2015). Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting. Trends in Biochemical Sciences, 40(5), 265-274. doi:10.1016/j.tibs.2015.03.006.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0026-B76A-7
Abstract
Programmed −1 ribosomal frameshifting (−1PRF) is an mRNA recoding event commonly utilized by viruses and bacteria to increase the information content of their genomes. Recent results have implicated −1PRF in quality control of mRNA and DNA stability in eukaryotes. Biophysical experiments demonstrated that the ribosome changes the reading frame while attempting to move over a slippery sequence of the mRNA – when a roadblock formed by a folded downstream segment in the mRNA stalls the ribosome in a metastable conformational state. The efficiency of −1PRF is modulated not only by cis-regulatory elements in the mRNA but also by trans-acting factors such as proteins, miRNAs, and antibiotics. These recent results suggest a molecular mechanism and new important cellular roles for −1PRF.