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Journal Article

Reflections of word processing in the insular cortex: A sub-regional parcellation based functional assessment

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Zaccarella,  Emiliano
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Friederici,  Angela D.
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Zaccarella, E., & Friederici, A. D. (2015). Reflections of word processing in the insular cortex: A sub-regional parcellation based functional assessment. Brain and Language, 142, 1-7. doi:10.1016/j.bandl.2014.12.006.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-BA35-3
Abstract
Knowledge about the neuroanatomy of the human brain has exponentially grown in the last decades leading to finer-grained sub-regional parcellations. The goal of this functional Magnetic Resonance Imaging (fMRI) study was to specify the involvement of the insula during visual word processing using a sub-regional parcellation approach. Specifically, we assessed: (1) the number of active voxels falling in each sub-insular cluster; (2) the signal intensity difference between word and letter strings within clusters; (3) the subject-specific cluster selectivity; (4) the lateralization between left and right clusters. We found that word compared to letter string processing was strongly sub-regional sensitive within the anterior-dorsal cluster only, and was left-lateralized. Interestingly, this sensitivity held at both group level and individual level. This study demonstrates that integrating hemodynamic activity with sub-topographic architecture can generate an enriched understanding of sub-regional functional specializations in the human brain.