English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5

MPS-Authors
/persons/resource/persons117822

Xiao,  Yaqiong
School of Education, Guangzhou University, China;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19643

Friederici,  Angela D.
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Xiao, Y., Zhai, H., Friederici, A. D., & Jia, F. (2016). The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5. Brain Imaging and Behavior, 10(1), 50-59. doi:10.1007/s11682-015-9362-z.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0026-BA43-3
Abstract
In recent years, research on human functional brain imaging using resting-state fMRI techniques has been increasingly prevalent. The term “default mode” was proposed to describe a baseline or default state of the brain during rest. Recent studies suggested that the default mode network (DMN) is comprised of two functionally distinct subsystems: a dorsal-medial prefrontal cortex (DMPFC) subsystem involved in self-oriented cognition (i.e., theory of mind) and a medial temporal lobe (MTL) subsystem engaged in memory and scene construction; both subsystems interact with the anterior medial prefrontal cortex (aMPFC) and posterior cingulate (PCC) as the core regions of DMN. The present study explored the development of DMN core regions and these two subsystems in both hemispheres from 3- to 5-year-old children. The analysis of the intrinsic activity showed strong developmental changes in both subsystems, and significant changes were specifically found in MTL subsystem, but not in DMPFC subsystem, implying distinct developmental trajectories for DMN subsystems. We found stronger interactions between the DMPFC and MTL subsystems in 5-year-olds, particularly in the left subsystems that support the development of environmental adaptation and relatively complex mental activities. These results also indicate that there is stronger right hemispheric lateralization at age 3, which then changes as bilateral development gradually increases through to age 5, suggesting in turn the hemispheric dominance in DMN subsystems changing with age. The present results provide primary evidence for the development of DMN subsystems in early life, which might be closely related to the development of social cognition in childhood.