Modulation of defensive behavior by Transient Receptor Potential Vanilloid 
Type-1 (TRPV1) Channels

Aguiar, D. C.; Moreira, F. A.; Terzian, A. L.; Fogaca, M. V.; Lisboa, S. F.; Wotjak, C. T.; Guimaraes, F. S.

doi:10.1016/j.neubiorev.2014.03.026

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Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels

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Terzian, A. L.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Wotjak, C. T.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Aguiar, D. C., Moreira, F. A., Terzian, A. L., Fogaca, M. V., Lisboa, S. F., Wotjak, C. T., et al. (2014). Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 46, 418-428. doi:10.1016/j.neubiorev.2014.03.026.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-DF03-3

Abstract

The Transient Receptor Potential Vanilloid Type-1 (TRPV1) was first characterized in primary afferent fibers as a receptor for capsaicin (the pungent ingredient of chili peppers). Later on, this cation-permeable ion channel was also described in the central nervous system, where its main putative endogenous ligand is N-arachidonoyl ethanolamide (an endocannabinoid, also known as anandamide). Recent results employing genetic, pharmacological and histochemical techniques indicate that TRPV1 tonically modulate anxiety, fear and panic responses in brain regions related to defensive responses, such as the dorsal periaqueductal gray, the hippocampus and the medial prefrontal cortex. Genetic deletion or antagonism of this ion channel induces anxiolytic-like effects in several animal models. The main mechanism responsible for TRPV1-mediated effects on anxiety seems to involve facilitation of glutamatergic neurotransmission. In addition, there is evidence for interactions with other neurotransmitter systems, such as nitric oxide and endocannabinoids. (C) 2014 Elsevier Ltd. All rights reserved.