MicroRNA-9 controls dendritic development by targeting REST

Giusti, Sebastian A.; Vogl, Annette M.; Brockmann, Marisa M.; Vercelli, Claudia A.; Rein, Martin L.; Truembach, Dietrich; Wurst, Wolfgang; Cazalla, Demian; Stein, Valentin; Deussing, Jan M.; Refojo, Damian

doi:10.7554/eLife.02755

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

MicroRNA-9 controls dendritic development by targeting REST

MPS-Authors

/persons/resource/persons138198

Giusti, Sebastian A.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80568

Vogl, Annette M.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons98277

Brockmann, Marisa M.
external;
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

Vercelli, Claudia A.
Department of Molecular Neurobiology, Instituto de Investigacion en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society;

/persons/resource/persons80301

Deussing, Jan M.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80487

Refojo, Damian
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

e02755.full.pdf
(Any fulltext), 4MB

Supplementary Material (public)

There is no public supplementary material available

Citation

Giusti, S. A., Vogl, A. M., Brockmann, M. M., Vercelli, C. A., Rein, M. L., Truembach, D., et al. (2014). MicroRNA-9 controls dendritic development by targeting REST. ELIFE, 3: UNSP e02755. doi:10.7554/eLife.02755.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-CE4D-5

Abstract

MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitors, its role in dendritic and synaptic development remains largely unknown. In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.