Different patterns of regional brain activation during emotional stimulation in 
alexithymics in comparison with normal controls a positron emission tomography 
(PET) study with O-15- H2O and emotional stimulation by way of autobiographic 
recall

Huber, M.; Herholz, Karl; Habedank, B.; Thiel, A.; Müller-Küppers, M.; Ebel, H.; Subic-Wrana, C.; Kohle, K.; Heiss, Wolf-Dieter

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Different patterns of regional brain activation during emotional stimulation in alexithymics in comparison with normal controls a positron emission tomography (PET) study with O-15- H2O and emotional stimulation by way of autobiographic recall

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Herholz, Karl
Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Thiel, A.
Klinisches PET, Neurologische Abteilung, Max-Planck-Institut für neurologische Forschung, Managing Director: D. Yves von Cramon, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Heiss, Wolf-Dieter
Wolf-Dieter Heiss, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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引用

Huber, M., Herholz, K., Habedank, B., Thiel, A., Müller-Küppers, M., Ebel, H., Subic-Wrana, C., Kohle, K., & Heiss, W.-D. (2002). Different patterns of regional brain activation during emotional stimulation in alexithymics in comparison with normal controls a positron emission tomography (PET) study with O-15- H2O and emotional stimulation by way of autobiographic recall. Psychotherapie Psychosomatik Medizinische Psychologie, 52(11), 469-478.

引用: https://hdl.handle.net/11858/00-001M-0000-0026-D3F3-9

要旨

Objective: This study was designed to determine patterns of regional brain activation during emotional stimulation in alexithymics as compared with normal controls. Method: We used O-15-water positron emission tomography and an emotional stimulation paradigm based upon autobiographic recall of either happy, sad or emotionally neutral situations. 10 normal subjects without medical or psychiatrical history were compared with 9 patients with somatoform disorder without any other DSM- IV diagnosis. TAS-20 was used as a measure for alexithymia, depression was measured using BDI. Results: Normal controls showed significantly greater activation than alexithymics in cingulate areas, corpus callosum, and right superior and inferior frontal gyrus. Alexithymics activated significantly more in cuneus and precuneus, thalamus (pulvinar), left medial frontal, right inferior temporal, left superior temporal regions, left precentral gyrus, and the cerebellum. Conclusions: During emotional autobiographic recall, alexithymia, either trait or state, is characterized by utilization of different brain regions when compared to normal controls. The areas activated by alexithymic persons largely comprise of language related regions, leaving out limbic and paralimbic areas.