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Magnetic resonance angiography of thromboembolic stroke in rats: Indicator of recanalization probability and tissue survival after recombinant tissue plasminogen activator treatment

MPG-Autoren
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Hilger,  Thomas
Konstantin-Alexander Hossmann, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Niessen,  Frank
Konstantin-Alexander Hossmann, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Diedenhofen,  Michael
In-vivo-NMR, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Hossmann,  Konstantin-Alexander
Konstantin-Alexander Hossmann, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Hoehn,  Mathias
In-vivo-NMR, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Zitation

Hilger, T., Niessen, F., Diedenhofen, M., Hossmann, K.-A., & Hoehn, M. (2002). Magnetic resonance angiography of thromboembolic stroke in rats: Indicator of recanalization probability and tissue survival after recombinant tissue plasminogen activator treatment. Journal of Cerebral Blood Flow and Metabolism, 22(6), 652-662.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0026-D68D-8
Zusammenfassung
Copyright 2002 by the International Society for Cerebral Blood Flow and Metabolism
Magnetic resonance angiography (MRA) was performed in a thromboembolic stroke model of the rat to chatacterize intracranial vessel occlusion patterns and to test its predictive power for tissue recovery after recombinant tissue plasminogen activator (rt-PA) treatment. After rt-PA-treated selective middle cerebral artery (MCA) occlusion, full recanalization was observed in two of three animals, whereas additional occlusion of the circle of Willis (CW) resulted in full vascular flow restitution in only one of six rats. Tissue reper-fusion markedly lagged the onset of treatment, and the delay correlated with the pattern of vessel occlusion (20 to 23 minutes for selective MCA occlusion vs. 71 to 79 minutes for combined MCA/CW occlusion). In lateral cortex and striatum the apparent diffusion coefficient decreased to 78 +/- 15% of control after embolization, recovered to 80% to 85% after rt-PA treatment of selective MCA occlusion, but further declined to 66% to 69% after combined MCA/CW occlusion. Correspondingly, T. relaxation time increased to 107% to 118% of control after selective MCA occlusion and to 112% to 124% after combined MCA/CW occlusion in these regions. The present investigation shows that MRA provides valuable information on the severity of thromboembolic stroke and has the power to predict, before the initiation of treatment, the functional tissue outcome after rt-PA-induced thrombolysis.