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Journal Article

Recent mechanistic insight into eukaryotic ribosomes.

MPS-Authors
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Rodnina,  M. V.
Department of Physical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Wintermeyer,  W.
Research Group of Ribosome Dynamics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Rodnina, M. V., & Wintermeyer, W. (2009). Recent mechanistic insight into eukaryotic ribosomes. Current Opinion in Cell Biology, 21(3), 435-443. doi:10.1016/j.ceb.2009.01.023.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0026-DBF2-D
Abstract
Ribosomes are supramolecular ribonucleoprotein particles that synthesize proteins in all cells. Protein synthesis proceeds through four major phases: initiation, elongation, termination, and ribosome recycling. In each phase, a number of phase-specific translation factors cooperate with the ribosome. Whereas elongation in prokaryotes and eukaryotes involve similar factors and proceed by similar mechanisms, mechanisms of initiation, termination, and ribosome recycling, as well as the factors involved, appear quite different. Here, we summarize recent progress in deciphering molecular mechanisms of eukaryotic translation. Comparisons with prokaryotic translation are included, emphasizing emerging patterns of common design.