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Patent

Chemical synthesis of phosphatidylinositol mannoside glycans from Mycobacterium tuberculosis

MPS-Authors
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Seeberger,  Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121567

Lepenies,  Bernd
Bernd Lepenies, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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2156945.pdf
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Citation

Seeberger, P. H., Boonyarattanakalin, S., & Lepenies, B.(2010). Chemical synthesis of phosphatidylinositol mannoside glycans from Mycobacterium tuberculosis.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-5F5F-1
Abstract
The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM1 to PIM6) is reported. The invention
relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the
sulfhydryl group, a protein, a fluorescent probe, or a solid phase. The invention further relates to vaccines comprising the PIMs
linked to a carrier protein or an antigen.