Chemical synthesis of phosphatidylinositol mannoside glycans from Mycobacterium 
tuberculosis

Seeberger, Peter H.; Boonyarattanakalin, Siwarutt; Lepenies, Bernd

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特許

Chemical synthesis of phosphatidylinositol mannoside glycans from Mycobacterium tuberculosis

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Seeberger, Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Lepenies, Bernd
Bernd Lepenies, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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引用

Seeberger, P. H., Boonyarattanakalin, S., & Lepenies, B.(2010). Chemical synthesis of phosphatidylinositol mannoside glycans from Mycobacterium tuberculosis.

引用: https://hdl.handle.net/11858/00-001M-0000-0027-5F5F-1

要旨

The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM1 to PIM6) is reported. The invention
relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the
sulfhydryl group, a protein, a fluorescent probe, or a solid phase. The invention further relates to vaccines comprising the PIMs
linked to a carrier protein or an antigen.