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Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide PS-II, methods of synthesis and uses thereof, in particular as a vaccine

MPS-Authors
/persons/resource/persons121849

Seeberger,  Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121691

Oberli,  Matthias
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121394

Hecht,  Mary-Lyn
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Seeberger, P. H., Oberli, M., & Hecht, M.-L.(2012). Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide PS-II, methods of synthesis and uses thereof, in particular as a vaccine.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-5F76-B
Abstract
The present invention provides an oligosaccharide-protein
conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide,
derived from the repeating unit of the Clostridium difjicile glycopolymer
PS-II and a protein carrier. More specifically, the oligosaccharide is
the hexasaccharide having the following formula (I) wherein R is a linker or
spacer group. In a specific embodiment of the invention, R is (CH2)nNHz,
with n being an integer from 2 to 50. The present invention also provides the
use of said oligosaccharide and said oligosaccharide-protein conjugate for
the treatment or prevention of a disease caused by the pathogen Clostridium
difjicile. In still further aspects, the present invention also provides a favourable
method for preparing said oligosaccharide and said oligosaccharide-protein
conjugate.