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Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide PS-II, methods of synthesis and uses thereof, in particular as a vaccine

MPS-Authors
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Seeberger,  Peter H.
Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Oberli,  Matthias
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Hecht,  Mary-Lyn
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Abstract
The present invention provides an oligosaccharide-protein conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide, derived from the repeating unit of the Clostridium difjicile glycopolymer PS-II and a protein carrier. More specifically, the oligosaccharide is the hexasaccharide having the following formula (I) wherein R is a linker or spacer group. In a specific embodiment of the invention, R is (CH2)nNHz, with n being an integer from 2 to 50. The present invention also provides the use of said oligosaccharide and said oligosaccharide-protein conjugate for the treatment or prevention of a disease caused by the pathogen Clostridium difjicile. In still further aspects, the present invention also provides a favourable method for preparing said oligosaccharide and said oligosaccharide-protein conjugate.