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Journal Article

Reduced default mode network connectivity in schizophrenia patients

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Deserno,  Lorenz
Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany;
Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Neurology, Otto von Guericke University Magdeburg, Germany;

Schlagenhauf,  Florian
Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany;
Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Pankow, A., Deserno, L., Walter, M., Fydrich, T., Bermpohl, F., Schlagenhauf, F., et al. (2015). Reduced default mode network connectivity in schizophrenia patients. Schizophrenia Research, 165(1), 90-93. doi:10.1016/j.schres.2015.03.027.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0027-7E56-A
Abstract
In the present study, we explored possible alterations in the default mode network (DMN) and its functional connectivity in 41 schizophrenia patients and 42 age-matched healthy controls. Schizophrenia patients displayed reduced activation in the ventromedial prefrontal cortex, left superior temporal gyrus including auditory cortex and temporal pole. Psychophysiological interaction analysis revealed reduced connectivity between left superior temporal gyrus including auditory cortex and the left temporal pole in schizophrenia patients compared to healthy subjects.