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Journal Article

Dual-Frequency Calcium-Responsive MRI Agents

MPS-Authors
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Kadjane,  P
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hagberg,  GE
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

http://onlinelibrary.wiley.com/doi/10.1002/chem.201400159/pdf
(Publisher version)

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Citation

Kadjane, P., Platas-Iglesias, C., Boehm-Sturm, P., Truffault, V., Hagberg, G., Hoehn, M., et al. (2014). Dual-Frequency Calcium-Responsive MRI Agents. Chemistry – A European Journal, 20(24), 7351-7362. doi:10.1002/chem.201400159.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-800D-3
Abstract
Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set of dual-frequency calcium-responsive MRI agents are reported. These are paramagnetic, fluorine-containing complexes that produce remarkably high MRI signal changes at the 1H and 19F frequencies at varying Ca2+ concentrations. The nature of the processes triggered by Ca2+ was revealed, allowing a better understanding of these complex systems and their further improvement. The findings indicate that these double-frequency tracers hold great promise for development of novel functional MRI methods.