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Inferring neural population dynamics from multiple partial recordings of the same neural circuit

MPG-Autoren
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Macke,  JH
Research Group Computational Vision and Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Turaga, S., Buesing, L., Packer, A., Dalgleish, H., Pettit, N., Hausser, M., et al. (2014). Inferring neural population dynamics from multiple partial recordings of the same neural circuit. In C. Burges, L. Bottou, M. Welling, Z. Ghahramani, & K. Weinberger (Eds.), Advances in Neural Information Processing Systems 26 (pp. 539-547). Red Hook, NY, USA: Curran.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0027-80BF-6
Zusammenfassung
Simultaneous recordings of the activity of large neural populations are extremely valuable as they can be used to infer the dynamics and interactions of neurons in a local circuit, shedding light on the computations performed. It is now possible to measure the activity of hundreds of neurons using 2-photon calcium imaging. However, many computations are thought to involve circuits consisting of thousands of neurons, such as cortical barrels in rodent somatosensory cortex. Here we contribute a statistical method for stitching'' together sequentially imaged sets of neurons into one model by phrasing the problem as fitting a latent dynamical system with missing observations. This method allows us to substantially expand the population-sizes for which population dynamics can be characterized---beyond the number of simultaneously imaged neurons. In particular, we demonstrate using recordings in mouse somatosensory cortex that this method makes it possible to predict noise correlations between non-simultaneously recorded neuron pairs.