Long lasting activity of nociceptive muscular afferents facilitates bilateral 
flexion reflex pattern in the feline spinal cord.

Schomburg, E. D.; Steffens, H.; Pilyavskii, A. I.; Maisky, V. A.; Brück, W.; Dibaj, P.; Sears, T. A.

doi:10.1016/j.neures.2015.01.003

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Long lasting activity of nociceptive muscular afferents facilitates bilateral flexion reflex pattern in the feline spinal cord.

MPS-Authors

/persons/resource/persons41376

Steffens, H.
Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society;

External Resource

http://www.sciencedirect.com/science/article/pii/S0168010215000048/pdfft?md5=74df78d12beb9fe0372b9a8120f3a311&pid=1-s2.0-S0168010215000048-main.pdf
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Schomburg, E. D., Steffens, H., Pilyavskii, A. I., Maisky, V. A., Brück, W., Dibaj, P., et al. (2015). Long lasting activity of nociceptive muscular afferents facilitates bilateral flexion reflex pattern in the feline spinal cord. Neuroscience Research, 95, 51-58. doi:10.1016/j.neures.2015.01.003.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-829D-F

Abstract

Chronic muscular limb pain requires the adoption of motor patterns distinct from the classic ipsilateral flexion, crossed extension and corresponding reciprocal inhibitions to acute exteroceptive stimulation. Using selective chemical activation of group III/IV afferents in gastrocnemius-soleus (GS) muscles we investigated bilaterally their reflex responses conditioned by (a) acute 'myositis' induced by intramuscular carrageenan; and (b) sub-acute 'myositis' induced by infusion of complete Freund's adjuvant (CFA). Reflex transmission was detected by monosynaptic testing and c-fos staining used to identify increased neuronal activity. In all control experiments with chemical stimulation of group III/IV afferents, ipsilateral responses conformed to the flexor reflex pattern. However, the expected contralateral facilitation of GS motoneurones occurred in fewer than 50% trials while only 9% of trials induced contralateral inhibition of flexor posterior-biceps-semitendinosus (PBSt) motoneurones. During carrageenan acute myositis contralateral PBSt was transiently facilitated by selective activation of group III/IV afferents. During CFA-induced myositis, contralateral only inhibition of GS motoneurones occurred instead of any facilitation, while bidirectionally a crossed facilitation of PBST dominated. These reflex changes were mirrored in an enhanced number of neurones with enhanced c-fos expression. Muscle pain, particularly if chronically persistent, requires another behavioural response pattern than acute exteroceptive pain