English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles

MPS-Authors
/persons/resource/persons127954

Franquelim,  Henri G.
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons15815

Schwille,  Petra
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Czogalla, A., Kauert, D. J., Franquelim, H. G., Uzunova, V., Zhang, Y., Seidel, R., et al. (2015). Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(22), 6501-6505. doi:10.1002/anie.201501173.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0027-A723-6
Abstract
We report a synthetic biology-inspired approach for the engineering of amphipathic DNA origami structures as membrane-scaffolding tools. The structures have a flat membrane-binding interface decorated with cholesterol-derived anchors. Sticky oligonucleotide overhangs on their side facets enable lateral interactions leading to the formation of ordered arrays on the membrane. Such a tight and regular arrangement makes our DNA origami capable of deforming free-standing lipid membranes, mimicking the biological activity of coat-forming proteins, for example, from the I-/F-BAR family.