Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane 
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Czogalla, Aleksander; Kauert, Dominik J.; Franquelim, Henri G.; Uzunova, Veselina; Zhang, Yixin; Seidel, Ralf; Schwille, Petra

doi:10.1002/anie.201501173

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Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles

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Franquelim, Henri G.
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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Schwille, Petra
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Czogalla, A., Kauert, D. J., Franquelim, H. G., Uzunova, V., Zhang, Y., Seidel, R., et al. (2015). Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles. Angewandte Chemie International Edition, 54(22), 6501-6505. doi:10.1002/anie.201501173.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-A723-6

Abstract

We report a synthetic biology-inspired approach for the engineering of amphipathic DNA origami structures as membrane-scaffolding tools. The structures have a flat membrane-binding interface decorated with cholesterol-derived anchors. Sticky oligonucleotide overhangs on their side facets enable lateral interactions leading to the formation of ordered arrays on the membrane. Such a tight and regular arrangement makes our DNA origami capable of deforming free-standing lipid membranes, mimicking the biological activity of coat-forming proteins, for example, from the I-/F-BAR family.