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Journal Article

The fusion pore.

MPS-Authors
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Lindau,  M.
Research Group of Nanoscale Cell Biology, MPI for Biophysical Chemistry, Max Planck Society;

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2167166.pdf
(Publisher version), 201KB

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Citation

Lindau, M., & de Toledo, A. (2003). The fusion pore. Biochimica et Biophysica Acta-Molecular Cell Research, 1641(2-3), 167-173. doi:10.1016/S0167-4889(03)00085-5.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0027-AAC7-2
Abstract
The secretory process requires many different steps and stages. Vesicles must be formed and transported to the target membrane. They must be tethered or docked at the appropriate sites and must be prepared for fusion (priming). As the last step, a fusion pore is formed and the contents are released. Release of neurotransmitter is an extremely rapid event leading to rise times of the postsynaptic response of less than 100 mus. The release thus occurs during the initial formation of the exocytotic fusion pore. To understand the process of synaptic transmission, it is thus of outstanding importance to understand the molecular structure of the fusion pore, what are the properties of the initial fusion pore, how these properties affect the release process and what other factors may be limiting the kinetics of release. Here we review the techniques currently employed in fusion pore studies and discuss recent data and opinions on exocytotic fusion pore properties.