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Journal Article

An electrochemical detector array to study cell biology on the nanoscale.

MPS-Authors
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Lindau,  M.
Research Group of Nanoscale Cell Biology, MPI for Biophysical Chemistry, Max Planck Society;

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http://iopscience.iop.org/0957-4484/13/3/309/pdf/0957-4484_13_3_309.pdf
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Citation

Dias, A. F., Dernick, G., Valero, V., Yong, M. G., James, C. D., Craighead, H. G., et al. (2002). An electrochemical detector array to study cell biology on the nanoscale. Nanotechnology, 13(3), 285-289. doi:10.1088/0957-4484/13/3/309.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-AED3-4
Abstract
Nanobiotechnology is a field that utilizes the techniques of nano- and microfabrication to study biosystems or to use biological material and principles to build new devices. As an example we discuss the development of a nanofabricated electrochemical detector array that reveals the spatio-temporal dynamics of exocytosis in single chromaffin cells. In a quantal release event a single vesicle fuses with the plasma membrane releasing its contents through the fusion pore. The time-resolved amperometric currents measured by the individual electrodes detecting different fractions of the released molecules allow determination of the time course as well as localization of quantal events. Such a device may be applicable to study the correlation of exocytotic events with signalling events that could be simultaneously monitored by fluorescence microscopy.