Metallacrowns as products of the aqueous medium self-assembly of 
histidinehydroxamic acid-containing polypeptides.

Cal, M.; Kotynia, A.; Jaremko, L.; Jaremko, M.; Lisowski, M.; Cebo, M.; Brasun, J.; Stefanowicz, P.

doi:10.1039/C5DT01267H

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Journal Article

Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides.

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Jaremko, L.
Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Jaremko, M.
Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society;

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http://pubs.rsc.org/en/content/articlepdf/2015/dt/c5dt01267h
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Citation

Cal, M., Kotynia, A., Jaremko, L., Jaremko, M., Lisowski, M., Cebo, M., et al. (2015). Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides. Dalton Transactions, 44(24), 11172-11181. doi: 10.1039/C5DT01267H.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-AFB7-B

Abstract

Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu2+ ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu2+ ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L4Cu5 complexes exist at physiological pH in the presence of Cu2+ ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.