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Journal Article

Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two−photon calcium imaging

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Denk,  Winfried
Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society;

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Friedrich,  Rainer W.
Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Wachowiak, M., Denk, W., & Friedrich, R. W. (2004). Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two−photon calcium imaging. Proceedings of the National Academy of Sciences of the United States of America, 101(24), 9097-9102. doi:10.1073/pnas.0400438101.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-9D00-5
Abstract
Glomeruli in the olfactory bulb are anatomically discrete modules receiving input from idiotypic olfactory sensory neurons. To examine the functional organization of sensory inputs to individual glomeruli, we loaded olfactory sensory neurons with a Ca2+ indicator and measured odorant−evoked presynaptic Ca2+ signals within single glomeruli by using two−photon microscopy in anaesthetized mice. Odorants evoked patterns of discrete Ca2+ signals throughout the neuropil of a glomerulus. Across glomeruli, Ca2+ signals occurred with equal probability in all glomerular regions. Within single glomeruli, the pattern of intraglomerular Ca2+ signals was indistinguishable for stimuli of different duration, identity, and concentration. Moreover, the response time course of the signals was similar throughout the glomerulus. Hence, sensory inputs to individual glomeruli are spatially heterogeneous but seem to be functionally indiscriminate. These results support the view of olfactory glomeruli as functional units in representing sensory information