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Journal Article

Crystallography on a chip

MPS-Authors
/persons/resource/persons92083

Barends,  Thomas
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;
Center for Free-Electron Laser Science, Notkestraße 85, 22607 Hamburg, Germany;
Max Planck Advanced Study Group, Notkestraße 85, 22607 Hamburg, Germany;

/persons/resource/persons94117

Lomb,  Lukas
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;
Center for Free-Electron Laser Science, Notkestraße 85, 22607 Hamburg, Germany;
Max Planck Advanced Study Group, Notkestraße 85, 22607 Hamburg, Germany;

/persons/resource/persons95189

Schlichting,  Ilme
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;
Center for Free-Electron Laser Science, Notkestraße 85, 22607 Hamburg, Germany;
Max Planck Advanced Study Group, Notkestraße 85, 22607 Hamburg, Germany;

External Resource

http://dx.doi.org/10.1107/S0907444911055296
(Publisher version)

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Citation

Zarrine-Afsar, A., Barends, T., Müller, C., Fuchs, M. R., Lomb, L., Schlichting, I., et al. (2012). Crystallography on a chip. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen), 68(3), 321-323. doi:10.1107/S0907444911055296.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-18C8-F
Abstract
A new chip-based crystal-mounting approach for rapid room-temperature data collection from numerous crystals is described. This work was motivated by the recent development of X-ray free-electron lasers. These novel sources deliver very intense femtosecond X-ray pulses that promise to yield high-resolution diffraction data of nanocrystals before their destruction by radiation damage. Thus, the concept of `diffraction before destruction' requires rapid replenishment of the sample for each exposure. The chip promotes the self-assembly of an array of protein crystals on a surface. Rough features on the surface cause the crystals to adopt random orientations, allowing efficient sampling of reciprocal space.