Cross-sex hormone treatment in male-to-female transsexual persons reduces serum 
brain-derived neurotrophic factor (BDNF)

Fuss, Johannes; Hellweg, Rainer; Van Caenegem, Eva; Briken, Peer; Stalla, Günter K.; T'Sjoen, Guy; Auer, Matthias K.

doi:10.1016/j.euroneuro.2014.11.019

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Cross-sex hormone treatment in male-to-female transsexual persons reduces serum brain-derived neurotrophic factor (BDNF)

MPS-Authors

/persons/resource/persons80539

Stalla, Günter K.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons127670

Auer, Matthias K.
Max Planck Institute of Psychiatry, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Fuss, J., Hellweg, R., Van Caenegem, E., Briken, P., Stalla, G. K., T'Sjoen, G., et al. (2015). Cross-sex hormone treatment in male-to-female transsexual persons reduces serum brain-derived neurotrophic factor (BDNF). EUROPEAN NEUROPSYCHOPHARMACOLOGY, 25(1), 95-99. doi:10.1016/j.euroneuro.2014.11.019.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-2591-2

Abstract

Serum levels of brain-derived neurotrophic factor (BDNF) are reduced in male-to-female transsexual persons (MtF) compared to male controls. It was hypothesized before that this might reflect either an involvement of BDNF in a biomechanism of transsexualism or to be the result of persistent social stress due to the condition. Here, we demonstrate that 12 month of cross-sex hormone treatment reduces serum BDNF levels in male-to-female transsexual persons independent of anthropometric measures. Participants were acquired through the European Network for the Investigation of Gender Incongruence (ENIGI). Reduced serum BDNF in MtF thus seems to be a result of hormonal treatment rather than a consequence or risk factor of transsexualism. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.