Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse
  1. Datensatz ansehen / 
  2. Datensatz Übersicht

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

MPG-Autoren
/persons/resource/persons80568

Vogl,  Annette M.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons98277

Brockmann,  Marisa M.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons138198

Giusti,  Sebastian A.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80429

Maccarrone,  Giuseppina
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons185862

Bauder,  Corinna A.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons185865

Richter,  Julia S.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80298

Dedic,  Nina
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80598

Wotjak,  Carsten T.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80561

Turck,  Christoph W.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80487

Refojo,  Damian
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Vogl, A. M., Brockmann, M. M., Giusti, S. A., Maccarrone, G., Vercelli, C. A., Bauder, C. A., et al. (2015). Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition. NATURE NEUROSCIENCE, 18(2), 239-251. doi:10.1038/nn.3912.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0028-FF9F-B
Zusammenfassung
Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by covalently conjugating Nedd8 to specific targets. However, its role in neurons, nonreplicating postmitotic cells, remains unexplored. Here we report that Nedd8 conjugation increased during postnatal brain development and is active in mature synapses, where many proteins are neddylated. We show that neddylation controls spine development during neuronal maturation and spine stability in mature neurons. We found that neddylated PSD-95 was present in spines and that neddylation on Lys202 of PSD-95 is required for the proactive role of the scaffolding protein in spine maturation and synaptic transmission. Finally, we developed Nae1(CamKll alpha-CreERT2) mice, in which neddylation is conditionally ablated in adult excitatory forebrain neurons. These mice showed synaptic loss, impaired neurotransmission and severe cognitive deficits. In summary, our results establish neddylation as an active post-translational modification in the synapse regulating the maturation, stability and function of dendritic spines.