Determining the role of microRNAs in psychiatric disorders

Issler, Orna; Chen, Alon

doi:10.1038/nrn3879

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Determining the role of microRNAs in psychiatric disorders

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Chen, Alon
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Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Issler, O., & Chen, A. (2015). Determining the role of microRNAs in psychiatric disorders. NATURE REVIEWS NEUROSCIENCE, 16(4), 201-212. doi:10.1038/nrn3879.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-D73D-3

Abstract

Recent studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have shown that manipulating the levels of particular mi-RNAs in the brain can alter behaviour. Here, we review recent studies in humans, animal models, cellular systems and bioinformatics that have advanced our understanding of the contribution of brain mi-RNAs to the regulation of behaviour in the context of psychiatric conditions. These studies highlight the potential of miRNA levels to be used in the diagnosis of psychiatric disorders and suggest that brain mi-RNAs could become novel treatment targets for psychiatric disorders.