Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and 
Dynamically Expressed

Rybak-Wolf, Agnieszka; Stottmeister, Christin; Glazar, Petar; Jens, Marvin; Pino, Natalia; Giusti, Sebastian; Hanan, Mor; Behm, Mikaela; Bartok, Osnat; Ashwal-Fluss, Reut; Herzog, Margareta; Schreyer, Luisa; Papavasileiou, Panagiotis; Ivanov, Andranik; Ohman, Marie; Refojo, Damian; Kadener, Sebastian; Rajewsky, Nikolaus

doi:10.1016/j.molcel.2015.03.027

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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

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Pino, Natalia
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Giusti, Sebastian
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Refojo, Damian
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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引用

Rybak-Wolf, A., Stottmeister, C., Glazar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., Herzog, M., Schreyer, L., Papavasileiou, P., Ivanov, A., Ohman, M., Refojo, D., Kadener, S., & Rajewsky, N. (2015). Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. MOLECULAR CELL, 58(5), 870-885. doi:10.1016/j.molcel.2015.03.027.

引用: https://hdl.handle.net/11858/00-001M-0000-0028-5D34-F

要旨

Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers.