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Conference Paper

Eliminating Pinned Spiral Waves in Cardiac Monolayer by Far Field Pacing

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Shajahan,  T. K.
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173574

Krinski,  Valentin
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons182783

Knyazeva,  Svetlana
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173583

Luther,  Stefan
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Citation

Shajahan, T. K., Krinski, V., Knyazeva, S., & Luther, S. (2014). Eliminating Pinned Spiral Waves in Cardiac Monolayer by Far Field Pacing. In 8th Conference of the ESGCO (pp. 151-152). IEEE.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-0F7D-D
Abstract
Fibrillation in the heart often consists of multiple spiral waves of electrical activation in cardiac tissue. To terminate these multiple waves, recently proposed Low Energy Antifibrillation Pacing (LEAP) uses a series of low energy pulses. This achieves an energy reduction of about 80% in animal experiments. To understand the mechanism of LEAP we study the interaction of electric pulses with pinned spiral waves in monolayers of cardiac cells. Optical mapping and controlled placing of heterogeneities allow us to observe the activation dynamics in these monolayers during field pulsing. We show that a pinned wave can be terminated by a series of pulses when one of the pulses falls in the vulnerable window of the pinned spiral.