Reduced intracortical inhibition and facilitation in the primary motor tongue 
representation of adults who stutter

Neef, Nicole; Paulus, Walter; Neef, Andreas; von Gudenberg, Alexander; Sommer, Martin

doi:10.1016/j.clinph.2011.02.003

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Reduced intracortical inhibition and facilitation in the primary motor tongue representation of adults who stutter

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Neef, Nicole
Max Planck Society;

Paulus, Walter
Max Planck Society;

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Neef, Andreas
Research Group Theoretical Neurophysics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

Sommer, Martin
Max Planck Society;

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Citation

Neef, N., Paulus, W., Neef, A., von Gudenberg, A., & Sommer, M. (2011). Reduced intracortical inhibition and facilitation in the primary motor tongue representation of adults who stutter. Clinical Neurophysiology, 122, 1802-1811. doi:10.1016/j.clinph.2011.02.003.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-11D7-1

Abstract

Objective: We aimed at detecting neurophysiological changes, in the primary motor tongue representation in adults with persistent stuttering. Methods: Using transcranial magnetic stimulation in 12 patients and 14 controls, we examined motor threshold, motor-evoked potential (MEP) input–output curve, short-term intracortical inhibition (SICI) and intracortical facilitation (ICF), based on eight trials per conditioning-test interval. Results: In controls inhibition of the MEP-amplitude at short inter-stimulus intervals (ISI) and facilitation of the MEP-amplitude at long ISIs was evident. Patients showed an inhibition at ISI 3 ms and weaker nonsignificant inhibition at ISI 2 ms; this delay of inhibitory activity was especially prominent in the right hemisphere. Facilitation was reduced at ISI 10 and 15 ms in patients. Furthermore, MEP input–output curve was steeper in patients. Motor thresholds did not differ between groups. Conclusions: In persistent stuttering intracortical excitability of the primary motor tongue representation is altered with a deviant time course for inhibitory activity in the right hemisphere and reduced pairedpulse facilitation. Significance: These results specify changes in intracortical networks possibly mediated by altered GABAergic regulations in persistent stuttering. Thus, a better understanding of pathomechanisms and a potential role in understanding pharmacological treatment responses emerge by using transcranial magnetic stimulation.