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Journal Article

Genomic control of receptor function

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Burnashev,  Nail
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Rozov,  Andrej
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Burnashev, N., & Rozov, A. (2000). Genomic control of receptor function. Cellular and Molecular Life Sciences, 57(11), 1499-1507. doi:10.1007/PL00000634.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-30BB-7
Abstract
Ionotropic ligand-gated channels constitute a messenger RNA (alternative splicing, editing) and sublarge superfamily of channels that provide a molecular unit composition. In addition, interaction of receptor basis for synaptic transmission in central and peripheral subunits with postsynaptic density proteins plays a regnervous systems. These channels are subjects of ge- ulatory role and determines targets of channel insertion. nomic regulation at different levels. The final functional In this review, taking glutamate receptor channels as properties of each particular channel are determined by well-studied example, we illustrate how each of these type of gene family, posttranscriptional alterations of steps may determine receptor function in synapses