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Journal Article

Connexin expression in electrically coupled postnatal rat brain neurons

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Rozov,  Andrej
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Burnashev,  Nail
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Feldmeyer,  Dirk
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Venance, L., Rozov, A., Blatow, M., Burnashev, N., Feldmeyer, D., & Monyer, H. (2000). Connexin expression in electrically coupled postnatal rat brain neurons. Proceedings of the National Academy of Sciences of the United States of America, 97(18), 10260-10265. doi:10.1073/pnas.160037097.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-32AC-A
Abstract
Electrical coupling by gap junctions is an important form of cell-to-cell communication in early brain development. Whereas glial cells remain electrically coupled at postnatal stages, adult vertebrate neurons were thought to communicate mainly via chemical synapses. There is now accumulating evidence that in certain neuronal cell populations the capacity for electrical signaling by gap junction channels is still present in the adult. Here we identified electrically coupled pairs of neurons between postnatal days 12 and 18 in rat visual cortex, somatosensory cortex, and hippocampus. Notably, coupling was found both between pairs of inhibitory neurons and between inhibitory and excitatory neurons. Molecular analysis by single-cell reverse transcription-PCR revealed a differential expression pattern of connexins in these identified neurons.