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Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes

MPG-Autoren
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Hutter,  Harald
Max Planck Research Group Developmental Genetics of the nervous system (Harald Hutter), Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Hutter, H., Vogel, B. E., Plenefisch, J. D., Norris, C. R., Proenca, R. B., Spieth, J., et al. (2000). Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes. Science, 287(5455), 989-994. doi:10.1126/science.287.5455.989.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0028-3537-B
Zusammenfassung
New proteins and modules have been invented throughout evolution. Gene birth dates in Caenorhabditis elegans range from the origins of cellular life through adaptation to a soil habitat. Possibly half are metazoan genes, having arisen sometime between the yeast-metazoan and nematode-chordate separations. These include basement membrane and cell adhesion molecules implicated in tissue organization. By contrast, epithelial surfaces facing the environment have specialized components invented within the nematode lineage. Moreover, interstitial matrices were likely elaborated within the vertebrate lineage. A strategy for concerted evolution of new gene families, as well as conservation of adaptive genes, may underlie the differences between heterochromatin and euchromatin.